Adaptation Studies with Ross River Virus: Laboratory Mice and Cell Cultures

Ross River virus.

BACKGROUND Ross River virus is Australia's most common and widespread arbovirus. It causes epidemic polyarthritis and is associated with significant morbidity and cost to society. OBJECTIVE This article aims to increase clinicians' awareness of the epidemiological and clinical features of Ross River virus and provide information regarding prevention, diagnosis and management. DISCUSSION Ros...

Climate variability and Ross River virus transmission.

OBJECTIVES (1) To examine the feasibility to link climate data with monthly incidence of Ross River virus (RRv). (2) To assess the impact of climate variability on the RRv transmission. DESIGN An ecological time series analysis was performed on the data collected between 1985 to 1996 in Queensland, Australia. METHODS Information on the notified RRv cases was obtained from the Queensland Dep...

Interaction of Ross River virus with the complement system.

In the absence of virus-specific antibody, Ross River virus failed to activate either the classical or alternative complement pathways. Instead, it inhibited the cleavage of C3 via both pathways. The virus did not appear to act by disrupting C3bBb complexes or by preventing cleavage of factor B by factor D. Instead Ross River virus was found to interfere with the actual cleavage of C3 by activa...

Studies on the replication of African Horse Sickness Virus in two different cell line cultures

Cytochemical studies in cell cultures infected with Rous sarcoma virus.

A procedure for obtaining a high percentage of Rous sarcoma virus-infected cells in cultures is described. Approximately 50% of the cells were infected by the 3rd day, a» determined by infec tive center assay. Vims assayed 24 hr after infection showed only IO1 infective particles/ml of supernatant fluid. Maximal titers ranged between IO5 and IO6infective particles/ml from the 5th day on. Cultu...